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Jandel Engineering sigma stat 2.03 software
Sigma Stat 2.03 Software, supplied by Jandel Engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sigma+stat+2%2E03+software/sigma+stat+statistical+software/pmc03001729-42-7-10
Average 90 stars, based on 1 article reviews
sigma stat 2.03 software - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Repeated dose of meloxicam induces genotoxicity and histopathological changes in cardiac tissue of mice.
Article Snippet: Meloxicam is the non-steroidal anti-inflammatory drug most used in small animals; however, studies on genotoxicity, oxidative stress, and histopathologic alterations in cardiac tissue are limited, especially at therapeutical doses used in these animals.. This study evaluated the toxic effects caused by the treatment involving repeated low at higher doses of meloxicam in mice, by genotoxicity, oxidative stress, and histopathological parameters.. Mice (CF1, male) received, by gavage, meloxicam at the therapeutic dose indicated for small animals (0.1mg/kg) and at higher doses (0.5 and 1mg/kg) for 28days.

Article Title: New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia.
Article Snippet: Previous behavioral and receptor binding studies on N-phenylpiperazine derivatives by our group indicated that LASSBio-579, LASSBio-580 and LASSBio-581 could be potential antipsychotic lead compounds.. The present study identified LASSBio-579 as the most promising among the three compounds, since it was the only one that inhibited apomorphine-induced climbing (5 mg/kg p.o.) and apomorphine-induced hypothermia (15 mg/kg p.o.).. Furthermore, LASSBio-579 (0.5 mg/kg p.o.) was effective in the ketamineinduced hyperlocomotion test and prevented the prepulse inhibition deficits induced by apomorphine, DOI and ketamine with different potencies (1 mg/kg, 0.5 mg/kg and 5 mg/kg p.o., respectively).

Article Title: Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.
Article Snippet: In an attempt to increase the affinity of our antipsychotic lead compound LASSBio-579 (1-((1-(4chlorophenyl)-1H-pyrazol-4-yl)methyl)-4-phenylpiperazine; (2)) for the 5-HT2A receptor, we synthesized five new N-phenylpiperazine derivatives using a linear synthetic route and the homologation strategy.. The binding profile of these compounds was evaluated for a series of dopaminergic, serotonergic and alpha-adrenergic receptors relevant for schizophrenia, using classical competition assays.. Increasing the length of the spacer between the functional groups of (2) proved to be appropriated since the affinity of these compounds increased 3e10-fold for the 5-HT2A receptor, with no relevant change in the affinity for the D2-like and 5-HT1A receptors.

Article Title: Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A
Article Snippet: Nine new terpenylated acylphloroglucinols, crassipins A−I, were isolated from the rhizomes and roots of the fern Elaphoglossum crassipes, and their structures were elucidated by analysis of spectroscopic data and chemical derivatization.. The absolute configurations of some of the compounds were established by CD and VCD in combination with a quantum mechanical method.. Crassipin A (1), the major acylphloroglucinol of the Et2O extract of E. crassipes, as well as its peracetylated derivative (8), displayed antidepressantlike activity in a mouse forced-swimming test when administered orally at a dose of 15 mg/kg.

Article Title: Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells
Article Snippet: 44 Statistical analyses Difference between different treatment groups was determined by one-way ANOVA followed by Bonferroni t-test using Sigma stat 2.03 software (Jandel Scientific).

Article Title: Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects.
Article Snippet: Analyses were performed using Sigma Stat 2.03 software (Jandel Scientific Corporation).

Article Title: Tissue-specific human beta-defensins (HBD)1, HBD2, and HBD3 secretion from human extra-placental membranes stimulated with Escherichia coli
Article Snippet: Statistical analysis was performed with the Sigma Stat 2.03 software (Jandel Scientific Software, Chicago, IL).



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